Thursday, March 5, 2015

Genetically Engineered Vaccines

Genetically Engineered Vaccines Now & Future
Human and Animal

The following are the vaccines that are already GMO:

HPV - see below

Hep B - see below

Rotavirus Vax -
Two rotavirus vaccines have been approved for use in the US. These vaccines differ in how they are made and in the number of doses prescribed when they are given. Both are given orally and contain genetically engineered live attenuated human rotavirus strains or hybrid human-bovine reassortment rotavirus strains.

New Flu vaccine made of insect parts
FDA approves first GMO flu vaccine containing reprogrammed insect virus

Trial Malaria vaccine -
The research is supported by a US$17 million, five-year grant from the Bill & Melinda Gates Foundation.

and another
Genetically modified mosquitos could be used to spread vaccine for malaria
A genetically engineered mosquito that vaccinates as it bites has been developed by scientists.
Researchers develop vaccine to treat nicotine addiction

As a result, the researchers had to develop a third kind of vaccine: a genetic vaccine, which works by binding the genetic sequence of a nicotine antibody to a non-harmful virus.  The virus is directed to go to the liver cells, and the genetic sequence of the antibody then inserts itself into those cells, causing the cells to produce a stream of the antibodies along with the other molecules they make.

“We can target almost any organ [with this type of vaccine], but the reason for using the liver is that it is a very good secretory organ,” Crystal told  “The liver is very good at making and secreting many proteins, so we just genetically modified the liver cells to also make antibodies against nicotine.”
GE Vaccines Are Commonplace
this is sent as a separate lesson


HPV Vaccine
more than a dozen of the Gardasil vaccine vials were found to be contaminated with rDNA of the Human Papillomavirus (HPV). What does this mean? The rDNA found inside the vaccine is not naturally occurring, rather it is the result of genetically modifying the genetic code of HPV. Furthermore, this genetically HPV is added to the vaccine during the manufacturing process.What’s even worse is that the vials were collected from around the globe, indicating that this is no isolated incident. Vials were collected from United States, Australia, New Zealand, Spain, Poland and France.

Hepatitis B Vaccine Hep B
Hep B Vaccine Licensed By FDA Without Adequate Proof of Long Term Safety - In 1986, the FDA gave Merck & Co. a license to market the first recombinant DNA hepatitis B vaccine, which replaced the old hepatitis B vaccines made from blood taken from human chronic hepatitis B virus carriers. In awarding Merck & Co. and, later, SmithKline Beecham Pharmaceuticals, licenses to market their genetically engineered hepatitis B vaccines in the U.S., the FDA allowed both drug companies to use "safety" studies which only included a few thousand children monitored for only four or five days after vaccination to check for reactions. As "proof" their hepatitis B vaccine is safe to be used in children, Merck & Co. stated in their 1993 product insert that "In a group of studies, 1636 doses of RECOMBIVAX HB were administered to 653 healthy infants and children (up to 10 years of age) who were monitored for 5 days after each dose."


"In 1996, Burton A. Waisbren, M.D., a cell biologist and infectious disease specialist, who is a founding member of the Infectious Disease Society of America and past President of the Infectious Disease Society of Milwaukee, pointed out in the Wisconsin Medical Journal that "there is an increasing number of reports in the refereed medical literature about demyelinizing diseases occurring after an individual has received the hepatitis B vaccination...since the hepatitis B virus itself has been reported to cause autoimmune problems, should we not be wary of giving antigens that seem to have triggered these problems?" Waisbren, in a presentation before a 1996 Institute of Medicine Vaccine Safety Forum, warned that genetically engineered hepatitis B vaccines contain polypeptide sequences that are present in human neurologic tissues such as myelin and that, by a mechanism called molecular mimicry, these polypeptides can act as autoantigens which can induce autoimmune demyelinating diseases of the brain such as multiple sclerosis. "

Rotavirus Vax
Merck’s RotaTeq, is a genetically engineered vaccine containing five human-cow reassortment strains of rotavirus, and GlaxoSmithKline’s Rotarix, is a genetically engineered vaccine created by isolating human rotavirus strain and uses African Green monkey kidney cells to produce the original viral seed stock from which the vaccine has been made.

Flu Vaccine - new one - To speed up flu vaccine production, the US FDA has approved a new insect-based, genetically engineered flu vaccine, as well as vaccines grown in cultures of dog kidney cells rather than eggs.
"In medicine, genetic engineering has been used to mass-produce insulin, human growth hormones, follistim (for treating infertility), human albumin, monoclonal antibodies, antihemophilic factors, vaccines,(Figure 0)and many other drugs. Vaccination generally involves injecting weak live, killed, or inactivated forms of viruses or their toxins into the person being immunized. Genetically engineered viruses are being developed that can still confer immunity, but lack the infectious sequences. Mouse hybridomas, cells fused together to create monoclonal antibodies have been humanised through genetic engineering to create human monoclonal antibodies. "
"Many are unaware that, despite the completely unknown long-term health consequences, GM vaccines are already in use and have been administered to American infants, children and adults for many years. Among them:
Hepatitis B vaccine: An inactivated recombinant DNA vaccine licensed for newborn infants and children in 1991, in which parts of the hepatitis B virus gene are cloned into yeast
Rotavirus vaccine: Live attenuated vaccines first licensed for infants and children licensed in 2006, which either contain genetically engineered human rotavirus strains or human-bovine hybridized reassortment rotavirus strains4
HPV vaccine (Gardasil or Cervarix): A recombinant vaccine licensed in 2006, which is prepared from virus-like particles (VLP's) and may also include use of an insect-cell Baculovirus expression vector system for production
Then there are those "hybrid" vaccines that cross the (very narrow) threshold into the GM food realm... for instance, goats are being genetically engineered to become "pharm animals" that carry vaccines in their milk. If the experiments being conducted by researchers from Texas A&M are successful, they will produce an "edible" malaria vaccine, with the ultimate goal being that children drinking the milk will become vaccinated in the process. If vaccines in your milk sounds a bit to "out there," it shouldn't, as there are many connections between the companies that make GM food and those that make GM vaccines."

And read further on the above page..............
GMOs in medicine and research
The Worst of Both Worlds -- Genetically Engineered Goats to Produce New Vaccine
Genetically engineered vaccines
‘Inherently unpredictable and possibly dangerous’
Broadening the approaches to developing more effective vaccines,   from 1999
A New Breed of Genetically Engineered Vaccines Will Take Control of Our DNA and Minds

Genetically Engineered Vaccines (Advances in Experimental Medicine and Biology)

Banana vaccines

People may soon be getting vaccinated for diseases like hepatitis B and cholera by simply taking a bite of banana. Researchers have successfully engineered bananas, potatoes, lettuce, carrots and tobacco to produce vaccines, but they say bananas are the ideal production and delivery vehicle.

When an altered form of a virus is injected into a banana sapling, the virus’ genetic material quickly becomes a permanent part of the plant’s cells. As the plant grows, its cells produce the virus proteins ­ but not the infectious part of the virus. When people eat a bite of a genetically engineered banana, which is full of virus proteins, their immune systems build up antibodies to fight the disease ­ just like a traditional vaccine.

GMO vaccines in organic livestock
Genetically engineered vaccines show up in use on household pets as well as organic livestock
From 2009 - not sure the status at the moment

"Vaccines are allowed in organic livestock production. I can understand that.  However ,recently  received an email from the Organic Consumers Organization indicating that genetically engineered (GE)vaccines are frequently used on organic livestock.

Now, according to federal law, genetically modified vaccines are excluded from organic livestock production. So that means currently, in opposition to federal law, genetically engineered vaccines are being used in organic livestock production."    and
"Hundreds of thousands of cats have been injected with a non-adjuvanted recombinant rabies vaccine spliced with the canary pox virus." "

April 3, 2012
"This recommendation concerns the class of livestock vaccines derived from excluded methods, commonly called GMO vaccines. There are approximately 73 registered animal vaccines, of which 13 are GMO . Only 2 vaccines, Bovine and Avian Salmonellosis, appear to be presently available only as GMO . At present livestock producers use all vaccines and are not required to determine if they are using non - GMO (conventional) or GMO derived vaccines. GMO vaccines are not legally allowed in organic production. This recommendation proposes a change which will allow GMO vaccines only in a declared emergency and, further, that at such time producers could use GMO vaccines without losing organic status of livestock. The recommendation also proposes changes to the definition of “emergency treatment program”. The entire recommendation applies to the class of vaccines derived from excluded methods, but does not foreclose petitions for individual vaccines or a class of vaccines to treat specific diseases."

Since this policy is a critical matter, with a Livestock Subcommittee proposal pending, we would like the NOP and/or other USDA agencies to provide information to the NOSB and the public at our next public NOSB meetings in October 2012 and Spring 2013 about any progress made or challenges encountered in responding to this request"

Canada does not allow GMO vaccines (CGSB, 2009

May of 2012
"Therefore we request that:
•NOP, and/or other appropriate USDA agencies, identify which currently available livestock vaccines are non - GMO and which are GMO derived, using the NOP definition  of excluded methods and with reference to specific pathogen strains, so that the NOSB, organic livestock producers, and organic certifiers can make informed decisions and meaningful recommendations .
• NOP, and/or other appropriate USDA agencies, encourage livestock vaccine manufacturer s to voluntarily make truthful label claims as to the presence or absence of GMOs using the NOP definitions of excluded methods.
• NOP, and/or other appropriate USDA agencies, establish a real time publicly accessible tracking system to identify non - GMO a nd GMO vaccines, using the NOP definitions of excluded methods and with reference to specific pathogen strains, when vaccines are registered with USDA"
GMO Vaccines in Organic  May 2012
"Under current regulations, GMO vaccines can't be used unless they are successfully petitioned for use on the National List. To date, no GMO vaccines have been petitioned, so one would assume that they're not being used in organic.

But, we know they are being used. This was first admitted to publicly by the National Organic Program staff at the May 2009 meeting of the National Organic Standards Board. Richard Matthews announced to the board that, in fact, since the beginning of the program, all vaccines had been routinely allowed in organic, without a review as to whether or not they were genetically engineered, and he recommended that, instead of the NOP enforcing the law against this violation, the NOSB should recommend a change in the law and that's what the NOSB did. " Scroll down to page 28 to see how complicated this is

GMO vaccines used in animals (and also affecting humans)
Vaccines Profoundly Threaten Sustainable Ag  November 2012
"Not only are children being genetically engineered by the new vaccines but the rights needed to stop this are being just as thoroughly subverted as laws and regulations have been to protect food and trees and animals from Monsanto.  In California, the giant biotech industry along with giant partners in the food industry lied to the public to defeat an initiative that would allow people a human right, the right to know what is in their foo.  But the biotech industry, allied with the medical organizations it controls via heavy funding, also pushed through a law that removes from Californians the right to even know what has been done to their children with GMO-vaccines. "

excerpts............I lived through this in the UK with foot and mouth destruction of so many animals..........Sheri.........
What is being done to farm animals in other countries goes further.  They are being slaughtered in the millions based on fictions.  For as aggressive and mendacious as industrial ag and the biotech industry are in telling the world that their genetically engineered crops and pesticides are not harming anything, they are even more militantly aggressive in projecting fear and inventing lies about nature.  Avian flu is a fiction, a hoax but it was used (perhaps even invented) by the Bush administration with ties to the biotech industry to destroy millions of poultry (and their bio-diversity) owned by small farmers.  The swine flu pandemic was another hoax, but it was the basis of wiping out rare swine breeds owned by small farmers in Haiti and the Coptics in Egypt.  Foot and Mouth disease, harmless to humans and something most animals get over, has been used as the justification for the mass slaughter by military of millions of cattle and hogs,
with animals being buried alive.

"For the sustainable ag to succeed, those involved must first see:
     that genetic engineering is not limited to crops and animals but is happening to their own families in the form of mandated GMO-vaccines for their children or flu shots for themselves,
    that non-threatening and even non-existent animal diseases are being used as a means to mass slaughter of innocent, healthy animals and thus to end real farming and ranching,
    that vaccines against those diseases promote the dangerous lie that these animal diseases are a threat, when in fact, the vaccines themselves and the removal of the human right to refuse them are the real and serious danger."

Rabies Vaccine in Bait for wildlife - from as far back as 1990
Can J Vet Res. 1990 October; 54(4): 504–507.
PMCID: PMC1255701    Vaccinia recombinant virus expressing the rabies virus glycoprotein: safety and efficacy trials in Canadian wildlife. The development and use of a vaccinia-rabies recombinant oral vaccine for the control of wildlife rabies; a link between Jenner and Pasteur.
Human Vaccinia Infection After Contact with a Raccoon Rabies Vaccine Bait --- Pennsylvania, 2009

"The program uses baits containing liquid vaccinia-rabies glycoprotein (V-RG) recombinant virus vaccine "

". This vaccine consists of a partially attenuated recombinant vaccinia virus (Copenhagen strain) with a gene encoding for rabies virus glycoprotein (2). Persons with immunosuppressive conditions or exfoliative dermatologic conditions are at greater risk for complications (e.g., progressive vaccinia or eczema vaccinatum) when exposed to the vaccinia virus contained in Raboral V-RG vaccine. "
use of modified live and genetically engineered (GE) vaccines in companion animals and farmed animals

Hundreds of thousands of cats have been injected with a non-adjuvanted recombinant rabies vaccine spliced with the canary pox virus used as a ‘vector’.

Some genetically engineered viral vaccines consist of chimera viruses that combine aspects of two infective viral genomes. One example is the live Flavivirus chimera vaccine against West Nile virus (WNV) in horses (PreveNile), registered in the United States in 2006. The structural genes of the attenuated yellow fever YF-17D backbone virus have been replaced with structural genes of the related WNV. Chimera avian influenza virus vaccines have been produced on a backbone of an existing, attenuated Newcastle disease virus vaccine strain to protection against wild-type influenza virus as well as against Newcastle disease virus.

The use of recombinant replication-defective, vectored vaccines that express the proteins of rabies virus raises several issues, and comes close on the heels of using modified adenoviruses, herpesviruses and pox viruses as delivery systems for foreign antigens in livestock and poultry vaccines, and in bait to vaccinate and immuno-contracept wildlife

These products range from diagnostic kits for feline leukemia virus to genetically engineered vaccines to prevent pseudorabies, a serious disease affecting swine. With the pseudorabies vaccines, tests kits have been developed to distinguish between infected animals and those vaccinated with genetically engineered vaccines. Since the first vaccine was licensed in 1979, a total of 79 genetically engineered biologics have been licensed; all but 20 are still being produced. More than a half-century ago, there were perhaps a half a dozen animal vaccines and other biologics available to farmers. Now there are 2,379 active product licenses for these animal vaccines and other biologics and 110 licensed manufacturers’.
Genetically Engineered Virus-Vectored Vaccines – Environmental Risk Assessment and Management Challenges New genetically engineered vaccines target Rift Valley fever
Researchers from the University of California, Davis, and elsewhere are reporting the development of two genetically engineered vaccines to combat the mosquito-borne Rift Valley fever, devastating to livestock and so far confined to Africa and the Middle East.

In developing the two vaccines, the researchers made use of the vaccinia virus, the same virus used to make the smallpox vaccine. They inactivated two vaccinia genes to weaken that virus and prevent it from causing disease, and inserted two Rift Valley fever genes to stimulate an immune response, thereby equipping the vaccinated animals to fight off infection.
Genetically Modified Organisms (Control of Release) Ordinance Live Recombinant Veterinary Vaccines
Evaluation of a Genetically Modified Foot–and–Mouth Disease Virus Vaccine Candidate Generated by Reverse Genetics
Many such vaccines have now been licensed or approved, and more are being developed. For example, a recombinant vaccinia virus has been used in Europe to vaccinate foxes against rabies, and a herpesvirus of turkey (HVT), used as a vaccine to protect chickens against Marek’s disease, has been engineered to produce antigens from Newcastle disease (ND) virus and infectious laryngotracheitis (ILT) virus and is being used to protect poultry against all three agents in a single dose Oral Immunization Of Native And Primed Animals With Transgenic Potato Tubers Expressing Lt-B (48)
Genetically Engineered
Virus-Vectored Vaccines – Environmental Risk
Assessment and Management Challenges
Stop a Dutch genetically engineered (GM)-vaccination study in foals from 3 days old until 6 months

Many believed the Hepatitis B was the first GM vaccine.  We were wrong as you can see in this text book here for further information:

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